Team
Meet the team.
Principal Investigator
Staff
Carla Zimmerman
Lab TechnicianEducation
University of Victoria, Victoria, BC, Canada Bachelor of Science, Biochemistry and Molecular BiologBio
Carla’s roles in the lab are maintaining hPSC cultures, managing inventories, training new personnel, navigating university bureaucracy, and generally keeping the lab running smoothly. Carla activities outside the lab include choral singing, playing violin, swing dancing, kayaking, drinking coffee, and attempting to keep up with her highly energetic toddler (whether or not there is a correlation between these last two is left as an exercise for the reader).
Education
University of British Columbia, Vancouver, BC, Canada Doctor of Philosophy, Zoology University of Toronto, Toronto, ON, Canada Masters, Medical Biophysics University of Saskatchewan, Saskatoon, SK, Canada Bachelors Certificate, Biology University of Saskatchewan, Saskatoon, SK, Canada Bachelors Degree, PhysicsBio
Cynthia was educated in Canada, obtaining her BSc at the University of Saskatchewan, MSc at the University of Toronto, and PhD at the University of British Columbia. She then moved to the United Kingdom for postdoctoral research at the Wellcome Trust Sanger Institute, MRC London Institute of Medical Science, University College London, and the University of Cambridge, focusing on stem cell epigenetics and physical biology. She pursued academic-industry translational research and development with Stemcell Technologies UK Ltd in collaboration with the Cambridge Stem Cell Institute as part of the European Union’s PluriMes research consortium. At the Zandstra Lab UBC location, Cynthia is supporting research operations including lab set-up, personnel recruitment, securing new funding, communications, laboratory management and oversight, and coaching junior research personnel. Her research focuses on how genetic and epigenetic regulatory networks, as well as microenvironmental, spatial, and biomechanical inputs influence blood development from pluripotent stem cell differentiation systems. In her spare time, Cynthia enjoys the great outdoors around Vancouver, particularly skiing and snowshoeing in winter, and hiking and kayaking in the summer, and playing ultimate frisbee. She’s also been a contemporary dance enthusiast for many years, and is the proud mom to two peachfaced lovebirds.
Education
Max Planck Institute for the Physics of Complex Systems, Dresden, Germany & University of Geneva, Geneva, Switzerland Postdoctoral Fellow (w/ F. Jülicher and M. Gonzalez-Gaitan), Biological Physics Andalusian Center for Developmental Biology (CABD), Sevilla, Spain Postdoctoral Fellow (w/ F. Casares), Computational Biology University of Sevilla, Sevilla, Spain Doctor of Philosophy (w/ A. Cordoba, M.C. Lemos), Systems Biology International University of Andalusia, Sevilla, Spain Masters, Bioinformatics and Computational Biology University of Sevilla, Sevilla, Spain Masters, Complex Systems and Nonlinear Phenomena University of Córdoba, Córdoba, Spain Bachelors Degree, PhysicsBio
Daniel, as expected from a theoretical physicist, likes wearing ‘Green Lantern’ symbology, discussing depths of ’The Matrix’ and playing board games. Additionally, Daniel is a movie maniac and collector of vinyl records. He plays drums and guitar, and equally loves vegan food, sushi and jamón serrano (no incongruence at all). Daniel leads the theoretical and computational side of the Z-lab. He’s actively involved in projects from different subfields in the lab, from differentiation patterns in organoid structures to differentiation trajectories in hematopoietic stem cells, where he is emphasizing in the control aspects of these lines. In this direction, Daniel is opening new research lines in the control of growth in functional organoids, and in the detection, quantification, analysis and control of emergent properties, with the latter research line being translationally applied through the different areas composing the Stem Cell Bioengineering lab.
Frank Hsu
Lab TechnicianPostdoctoral Fellows
Education
University of Alberta, Edmonton, Canada Doctor of Philosophy, Bioresource and Food Engineering Northwest A&F University, China Bachelor of Engineering, Food Quality and Safety.Bio
Jie completed her PhD under the co-supervision of professors David Bressler and Dominic Sauvageau. By integrating knowledge from different disciplines, she developed an automated bioprocessing platform that help improve fermentation productivity by over 40%. In the Zandstra lab, Jie applies her skills in process development and scale-up towards developing scalable processes to guide the differentiation of pluripotent stem cells. Outside the lab, Jie likes to do fermentation at home, bike around, and shoot photos.
Nancy Fang
Ph.D.Education
University of British Columbia, Vancouver, BC, Canada Doctor of Philosophy, Biochemistry and Molecular Biology Sun Yat-sen University, Guangzhou, China Bachelor of Science, BiotechnologyBio
Nancy completed her PhD in Prof Thibault Mayor’s lab at the Biochemistry and Molecular Biology Department of UBC where she combined proteomic, genetic, and molecular biology approaches to study the relationship between ubiquitination, an essential post-translational modification on proteins in eukaryotes, and the homeostasis of misfolded proteins under stress conditions, which is crucial for prevention of protein aggregation and maintenance of cell fitness. As one of Nancy’s research interests is to advance in situ proteomic technology, she joined Dr. George Church’s lab at Harvard Medical School after graduation, where she was involved in developing an in situ sequencing technology enabling spontaneous detection of multiple protein, mRNA, miRNA targets in intact, fixed tissue samples. She also developed a synthetic biology platform for rapid generation of small affinity proteins for multiple targets during her time in the Church, so she is a huge fan for synthetic biology. Nancy joined the Zandstra lab at October 2018 and aims to bring this state of the art in situ sequencing technology to the lab and UBC.
Education
Massachusetts Institute of Technology, Boston, MA Doctor of Philosophy, Biological Engineering University of Washington, Seattle, ON Bachelor of Science, BioengineeringBio
Ross completed his PhD under Ron Weiss and Domitilla Del Vecchio at MIT, where he developed genetic control systems to make synthetic gene circuits operate robustly regardless of the messy cellular context inside mammalian cells. As a control freak, Ross is working in the Zandstra Lab to build genetic controllers to control cell fate decisions and ultimately control the behavior of cell therapies. Outside of the lab, you can probably find Ross playing sports, reading/watching sci-fi, or trying out a new board game.
Education
University of Oxford, Oxford, England Doctor of Philosophy, Medical Science Harvard University, Boston, USA Bachelor of Arts, Molecular and Cellular Biology, secondary AstrophysicsBio
Yale completed his PhD in Prof Tudor Fulga’s lab at the Weatherall Institute of Molecular Medicine where he developed a technology for precisely tuning gene expression levels in mammalian cells. In the Zandstra lab, Yale aims to apply his experience in genome engineering, microRNAs and synthetic biology towards generating cellular therapies from pluripotent stem cells. Outside of the lab, Yale loves sharing his passion for science with others as well as playing and watching sports.Students
Asel Primbetova
Education
Northeastern University, Boston, USA BachelorBio
My research is focused on development of three-dimensional artificial thymic niche. Despite the great potential of T cells therapeutics in immunotherapy, there are no currently available platforms for scalable generation of the cells. To address this problem, I am designing an artificial thymic niche for efficient, robust and scalable T cells production and their transplantation into patients. Currently, I work on synthesis and testing of thymus mimicking injectable biomaterial containing key cell signaling molecules that support differentiation of hematopoietic stem cells (HSCs) into therapeutic T cells. I aspire that my research will expand our knowledge about T cells differentiation and result in engineering a system that overcomes the challenges of T cell therapeutics production. Outside of the lab, I enjoy teaching Zumba classes, playing squash, traveling and spending time with my family and friends.
Education
Dalhousie University, Halifax, Canada Master of Science, Microbiology and Immunology Dalhousie University, Halifax, Canada Bachelor of Science, Microbiology and ImmunologyBio
Once upon a time, Beth lived in a distant eastern land, Halifornia. There her first love was viruses, an evasive love, but infectious nonetheless. Alas, as life goes, she continued her journey west and a new love stemmed. While this new romance felt cell-fish, Beth dove right in to exploring the early stages of development of blood and immune cells. Now, she is trying to understand how the spatial context of developing cells can tune what type of cell they become. It’s bloody exciting. In her new life in BC, Beth likes to run, cook, go up and then back down mountains (through a variety of methods) and make lots of bad puns.
Education
University of Toronto, Toronto, ON, Canada Masters, Immunology University of Toronto, Toronto, ON, Canada Bachelors of Science, ImmunologyBio
Cellular engineering is a crucial area in developing personalized medicine. Synthetic biology takes advantage of advancements in DNA synthesis, molecular and computational biology to design and engineer customized synthetic signaling pathways that allows for “smart” forward programming of the cell based on their transcriptomic state. Charles focuses on using synthetic biology to influence cell development and cell fate of pluripotent stem cells with the goal of generating specific cell types for regenerative immunotherapy. Always down for a drink. If you want to get me drunk, one drink is all it takes. Interesting include archery, guitar, video games and distracting people from their work.
John Edgar
Education
University of Toronto, Toronto, ON, Canada Masters, Biomedical Engineering University of Victoria, Victoria, BC, Canada Bachelor of Engineering, Biomedical EngineeringBio
I enjoy cooking food, fermenting food, and eating food. In a former life I worked in fabrication and I enjoy designing and building things that are of practical use (that’s why I’m an engineer). My dream job is to travel the pacific northwest coast in a tug boat searching for logs that fall off barges (ie. The Beachcombers).
Education
University of Toronto, Toronto, ON, Canada Bachelor of science, Molecular Genetics and PhysiologyBio
CAR-T cell therapy has revolutionized cancer treatment. While this approach has achieved remarkable success in blood cancers, the efficacy is relatively limited in solid tumors. Lauren is developing a T-cell compatible tumor-on-a-chip model to understand the reasons for CAR-T cell dysfunction in the solid tumor microenvironment. These insights will be used to inform design strategies for CAR-T cells with improved function in solid tumors. When she’s not in the lab, Lauren loves to run, ski, and explore new places around Vancouver.
Education
Queen’s University, Kinsgton, Canada Bachelors of Applied Science, Chemical EngineeringBio
The cells of our immune system, such as T cells, play a crucial role in detecting both pathogens and cancerous tissue, and then mounting a powerful, highly specific immune response to maintain the balance of our health. These cellular properties underline the potential for T cells to be employed as therapeutics for immunodeficiency, cancer treatment, and targeted immunotherapies. In my research I use high-dimensional spatial imaging to study the development of T cells in the human thymus, the organ where T cells are trained. I believe that by improving our understanding of the native spatiotemporal signals directing T cell development, we can identify unique developmental niches within the thymus, and translate this knowledge to drive the advancement of culture systems to produce mature T cells for use in emerging cell therapies. In my spare time you can find me seeking sunlight and adventure. I love to play soccer, hike, row, and catch as many sunrises and sunsets as possible (preferably on top of a mountain or on the ocean)!
