Publications

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TitleAuthor(s)JournalYearPMID
Human Embryonic Stem Cell-Derived Cardiomyocytes Regenerate the Infarcted Pig Heart but Induce Ventricular Tachyarrhythmias.Romagnuolo R, Masoudpour H, Porta-Sánchez A, Qiang B, Barry J, Laskary A, Qi X, Massé S, Magtibay K, Kawajiri H, Wu J, Valdman Sadikov T, Rothberg J, Panchalingam KM, Titus E, Li RK, Zandstra PW, Wright GA, Nanthakumar K, Ghugre NR, Keller G, Laflamme MA.Stem Cell Reports201931056479
Cell competition during reprogramming gives rise to dominant clones.Shakiba N, Fahmy A, Jayakumaran G, McGibbon S, David L, Trcka D, Elbaz J, Puri MC, Nagy A, van der Kooy D, Goyal S, Wrana JL, Zandstra PW.Science201930898844
Identifying Extrinsic versus Intrinsic Drivers of Variation in Cell Behavior in Human iPSC Lines from Healthy Donors.Vigilante A, Laddach A, Moens N, Meleckyte R, Leha A, Ghahramani A, Culley OJ, Kathuria A, Hurling C, Vickers A, Wiseman E, Tewary M, Zandstra PW; HipSci Consortium., Durbin R, Fraternali F, Stegle O, Birney E, Luscombe NM, Danovi D, Watt FM.Cell Rep201930784590
Context-explorer: Analysis of spatially organized protein expression in high-throughput screens.Ostblom J, Nazareth EJP, Tewary M, Zandstra PW.PLoS Comput Biol 201930601802
Patterned Optoelectronic Tweezers: A New Scheme for Selecting, Moving, and Storing Dielectric Particles and Cells.Zhang S, Shakiba N, Chen Y, Zhang Y, Tian P, Singh J, Chamberlain MD, Satkauskas M, Flood AG, Kherani NP, Yu S, Zandstra PW, Wheeler AR.Small 201830307718
Stem cell bioengineering: building from stem cell biology.Tewary M, Shakiba N, Zandstra PW.Nat Rev Genet 201830089805
Mechanics-guided developmental fate patterning.Tewary M, Zandstra PW.Nat Mater 201829941948
Modulating cell state to enhance suspension expansion of human pluripotent stem cells.Lipsitz YY, Woodford C, Yin T, Hanna JH, Zandstra PW.Proc Natl Acad Sci U S A 201829866848
Author Correction: A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies.Bahr C, von Paleske L, Uslu VV, Remeseiro S, Takayama N, Ng SW, Murison A, Langenfeld K, Petretich M, Scognamiglio R, Zeisberger P, Benk AS, Amit I, Zandstra PW, Lupien M, Dick JE, Trumpp A, Spitz F.Nature 201829769714
Chemically controlled aggregation of pluripotent stem cells.Lipsitz YY, Tonge PD, Zandstra PW.Biotechnol Bioeng 201829679475
Convenience versus Biological Significance: Are PMA-Differentiated THP-1 Cells a Reliable Substitute for Blood-Derived Macrophages When Studying in Vitro Polarization?Tedesco S, De Majo F, Kim J, Trenti A, Trevisi L, Fadini GP, Bolego C, Zandstra PW, Cignarella A, Vitiello L.Front Pharmacol 201829520230
Modeling signaling-dependent pluripotency with Boolean logic to predict cell fate transitions.Yachie-Kinoshita A, Onishi K, Ostblom J, Langley MA, Posfai E, Rossant J, Zandstra PW.Mol Syst Biol 201829378814
A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies.Bahr C, von Paleske L, Uslu VV, Remeseiro S, Takayama N, Ng SW, Murison A, Langenfeld K, Petretich M, Scognamiglio R, Zeisberger P, Benk AS, Amit I, Zandstra PW, Lupien M, Dick JE, Trumpp A, Spitz F.Nature 201829342133
FZD4 Marks Lateral Plate Mesoderm and Signals with NORRIN to Increase Cardiomyocyte Induction from Pluripotent Stem Cell-Derived Cardiac Progenitors.Yoon C, Song H, Yin T, Bausch-Fluck D, Frei AP, Kattman S, Dubois N, Witty AD, Hewel JA, Guo H, Emili A, Wollscheid B, Keller G, Zandstra PW.Stem Cell Reports 201829249665
Enhanced human hematopoietic stem and progenitor cell engraftment by blocking donor T cell-mediated TNFα signaling.Wang W, Fujii H, Kim HJ, Hermans K, Usenko T, Xie S, Luo ZJ, Ma J, Celso CL, Dick JE, Schroeder T, Krueger J, Wall D, Egeler RM, Zandstra PW.Sci Transl Med 201729263228
A stepwise model of reaction-diffusion and positional information governs self-organized human peri-gastrulation-like patterning.Tewary M, Ostblom J, Prochazka L, Zulueta-Coarasa T, Shakiba N, Fernandez-Gonzalez R, Zandstra PW.Development 201728870989
Steric Hindrance Assay for Secreted Factors in Stem Cell Culture.Zhou W, Mahshid SS, Wang W, Vallée-Bélisle A, Zandstra PW, Sargent EH, Kelley SO.ACS Sens 201728723184
Engineering cell fitness: lessons for regenerative medicine.Shakiba N, Zandstra PW.Curr Opin Biotechnol 201728551499
Engineering the haemogenic niche mitigates endogenous inhibitory signals and controls pluripotent stem cell-derived blood emergence.Rahman N, Brauer PM, Ho L, Usenko T, Tewary M, Zúñiga-Pflücker JC, Zandstra PW.Nat Commun 201728541275
Progenitor T-cell differentiation from hematopoietic stem cells using Delta-like-4 and VCAM-1.Shukla S, Langley MA, Singh J, Edgar JM, Mohtashami M, Zúñiga-Pflücker JC, Zandstra PW.Nat Methods 201728394335
Engineering a humanized bone organ model in mice to study bone metastases.Martine LC, Holzapfel BM, McGovern JA, Wagner F, Quent VM, Hesami P, Wunner FM, Vaquette C, De-Juan-Pardo EM, Brown TD, Nowlan B, Wu DJ, Hutmacher CO, Moi D, Oussenko T, Piccinini E, Zandstra PW, Mazzieri R, Lévesque JP, Dalton PD, Taubenberger AV, Hutmacher DW.Nat Protoc 201728253234
Achieving Efficient Manufacturing and Quality Assurance through Synthetic Cell Therapy Design.Lipsitz YY, Bedford P, Davies AH, Timmins NE, Zandstra PW.Cell Stem Cell 201728061350
Distinct signaling programs control human hematopoietic stem cell survival and proliferation.Knapp DJ, Hammond CA, Aghaeepour N, Miller PH, Pellacani D, Beer PA, Sachs K, Qiao W, Wang W, Humphries RK, Sauvageau G, Zandstra PW, Bendall SC, Nolan GP, Hansen C, Eaves CJ.Blood 201727827829
A 17-gene stemness score for rapid determination of risk in acute leukaemia.Ng SW, Mitchell A, Kennedy JA, Chen WC, McLeod J, Ibrahimova N, Arruda A, Popescu A, Gupta V, Schimmer AD, Schuh AC, Yee KW, Bullinger L, Herold T, Görlich D, Büchner T, Hiddemann W, Berdel WE, Wörmann B, Cheok M, Preudhomme C, Dombret H, et al.Nature 201627926740
Proneurogenic Ligands Defined by Modeling Developing Cortex Growth Factor Communication Networks.Yuzwa SA, Yang G, Borrett MJ, Clarke G, Cancino GI, Zahr SK, Zandstra PW, Kaplan DR, Miller FD.Neuron 201627545711
Distinguishing autocrine and paracrine signals in hematopoietic stem cell culture using a biofunctional microcavity platform.Müller E, Wang W, Qiao W, Bornhäuser M, Zandstra PW, Werner C, Pompe T.Sci Rep 201627535453
A Multi-Lineage Screen Reveals mTORC1 Inhibition Enhances Human Pluripotent Stem Cell Mesendoderm and Blood Progenitor Production.Nazareth EJP, Rahman N, Yin T, Zandstra PW.Stem Cell Reports 201627132889
miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells.Lechman ER, Gentner B, Ng SWK, Schoof EM, van Galen P, Kennedy JA, Nucera S, Ciceri F, Kaufmann KB, Takayama N, Dobson SM, Trotman-Grant A, Krivdova G, Elzinga J, Mitchell A, Nilsson B, Hermans KG, Eppert K, Marke R, Isserlin R, Voisin V, Bader GD, et al.Cancer Cell 201627070706
Quality cell therapy manufacturing by design.Lipsitz YY, Timmins NE, Zandstra PW.Nat Biotechnol 201627054995
Two-dimensional arrays of cell-laden polymer hydrogel modules.Wang Y, Li Y, Thérien-Aubin H, Ma J, Zandstra PW, Kumacheva E.Biomicrofluidics 201626858822
miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells.Lechman ER, Gentner B, Ng SW, Schoof EM, van Galen P, Kennedy JA, Nucera S, Ciceri F, Kaufmann KB, Takayama N, Dobson SM, Trotman-Grant A, Krivdova G, Elzinga J, Mitchell A, Nilsson B, Hermans KG, Eppert K, Marke R, Isserlin R, Voisin V, Bader GD, et al.Cancer Cell 201626832662
Proportional-Integral-Derivative (PID) Control of Secreted Factors for Blood Stem Cell Culture.Caldwell J, Wang W, Zandstra PW.PLoS One 201526348930
LIF signaling in stem cells and development.Onishi K, Zandstra PW.Development 201526130754
PI3K Phosphorylation Is Linked to Improved Electrical Excitability in an In Vitro Engineered Heart Tissue Disease Model System.Kana K, Song H, Laschinger C, Zandstra PW, Radisic M.Tissue Eng Part A 201526120935
Corrigendum: Genome-wide characterization of the routes to pluripotency.Hussein SM, Puri MC, Tonge PD, Benevento M, Corso AJ, Clancy JL, Mosbergen R, Li M, Lee DS, Cloonan N, Wood DL, Munoz J, Middleton R, Korn O, Patel HR, White CA, Shin JY, Gauthier ME, Cao KA, Kim JI, Mar JC, Shakiba N, et al.Nature 201526083747
CD24 tracks divergent pluripotent states in mouse and human cells.Shakiba N, White CA, Lipsitz YY, Yachie-Kinoshita A, Tonge PD, Hussein SM, Puri MC, Elbaz J, Morrissey-Scoot J, Li M, Munoz J, Benevento M, Rogers IM, Hanna JH, Heck AJ, Wollscheid B, Nagy A, Zandstra PW.Nat Commun 201526076835
Bringing Blood Stem Cell Phenotype, Genotype, and Function Closer Together.Qiao W, Zandstra PW.Cell Stem Cell 201526046754
The microwell-mesh: A novel device and protocol for the high throughput manufacturing of cartilage microtissues.Futrega K, Palmer JS, Kinney M, Lott WB, Ungrin MD, Zandstra PW, Doran MR.Biomaterials 201526010218
Stem cells: Chasing blood.Goyal S, Zandstra PW.Nature 201525686602
Genome-wide characterization of the routes to pluripotency.Hussein SM, Puri MC, Tonge PD, Benevento M, Corso AJ, Clancy JL, Mosbergen R, Li M, Lee DS, Cloonan N, Wood DL, Munoz J, Middleton R, Korn O, Patel HR, White CA, Shin JY, Gauthier ME, Lê Cao KA, Kim JI, Mar JC, Shakiba N, et al.Nature 201425503233
Transforming the promise of pluripotent stem cell-derived cardiomyocytes to a therapy: challenges and solutions for clinical trials.Prowse AB, Timmins NE, Yau TM, Li RK, Weisel RD, Keller G, Zandstra PW.Can J Cardiol 201425442434
Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal.Fares I, Chagraoui J, Gareau Y, Gingras S, Ruel R, Mayotte N, Csaszar E, Knapp DJ, Miller P, Ngom M, Imren S, Roy DC, Watts KL, Kiem HP, Herrington R, Iscove NN, Humphries RK, Eaves CJ, Cohen S, Marinier A, Zandstra PW, Sauvageau G.Science 201425237102
Local BMP-SMAD1 signaling increases LIF receptor-dependent STAT3 responsiveness and primed-to-naive mouse pluripotent stem cell conversion frequency.Onishi K, Tonge PD, Nagy A, Zandstra PW.Stem Cell Reports 201425068129
Intercellular network structure and regulatory motifs in the human hematopoietic system.Qiao W, Wang W, Laurenti E, Turinsky AL, Wodak SJ, Bader GD, Dick JE, Zandstra PW.Mol Syst Biol 201425028490
A microgroove patterned multiwell cell culture plate for high-throughput studies of cell alignment.Lücker PB, Javaherian S, Soleas JP, Halverson D, Zandstra PW, McGuigan AP.Biotechnol Bioeng 201424889796
A global assessment of stem cell engineering.Loring JF, McDevitt TC, Palecek SP, Schaffer DV, Zandstra PW, Nerem RM.Tissue Eng Part A 201424428577
Real-time monitoring and control of soluble signaling factors enables enhanced progenitor cell outputs from human cord blood stem cell cultures.Csaszar E, Chen K, Caldwell J, Chan W, Zandstra PW.Biotechnol Bioeng 201424284903
Blood stem cell fate regulation by Delta-1-mediated rewiring of IL-6 paracrine signaling.Csaszar E, Wang W, Usenko T, Qiao W, Delaney C, Bernstein ID, Zandstra PW.Blood 201424243972
Surfaceome profiling reveals regulators of neural stem cell function.DeVeale B, Bausch-Fluck D, Seaberg R, Runciman S, Akbarian V, Karpowicz P, Yoon C, Song H, Leeder R, Zandstra PW, Wollscheid B, van der Kooy D.Stem Cells 201424023036
Design and formulation of functional pluripotent stem cell-derived cardiac microtissues.Thavandiran N, Dubois N, Mikryukov A, Massé S, Beca B, Simmons CA, Deshpande VS, McGarry JP, Chen CS, Nanthakumar K, Keller GM, Radisic M, Zandstra PW.Proc Natl Acad Sci U S A 201324255110
Oct4 is required ~E7.5 for proliferation in the primitive streak.DeVeale B, Brokhman I, Mohseni P, Babak T, Yoon C, Lin A, Onishi K, Tomilin A, Pevny L, Zandstra PW, Nagy A, van der Kooy D.PLoS Genet 201324244203
High-throughput fingerprinting of human pluripotent stem cell fate responses and lineage bias.Nazareth EJ, Ostblom JE, Lücker PB, Shukla S, Alvarez MM, Oh SK, Yin T, Zandstra PW.Nat Methods 201324141495
InVERT molding for scalable control of tissue microarchitecture.Stevens KR, Ungrin MD, Schwartz RE, Ng S, Carvalho B, Christine KS, Chaturvedi RR, Li CY, Zandstra PW, Chen CS, Bhatia SN.Nat Commun 201323673632
Integrative network analysis of signaling in human CD34(+) hematopoietic progenitor cells by global phosphoproteomic profiling using TiO2 enrichment combined with 2D LC-MS/MS and pathway mapping.Guo H, Isserlin R, Chen X, Wang W, Phanse S, Zandstra PW, Paddison PJ, Emili A.Proteomics 201323401153
Blood stem cell products: toward sustainable benchmarks for clinical translation.Csaszar E, Cohen S, Zandstra PW.Bioessays 201323299858
High density continuous production of murine pluripotent cells in an acoustic perfused bioreactor at different oxygen concentrations.Baptista RP, Fluri DA, Zandstra PW.Biotechnol Bioeng 201322949074
PERT: a method for expression deconvolution of human blood samples from varied microenvironmental and developmental conditions.Qiao W, Quon G, Csaszar E, Yu M, Morris Q, Zandstra PW.PLoS Comput Biol 201223284283
Microenvironment-mediated reversion of epiblast stem cells by reactivation of repressed JAK-STAT signaling.Onishi K, Tonge PD, Nagy A, Zandstra PW.Integr Biol (Camb) 201222990140
HER2-targeted liposomal doxorubicin displays enhanced anti-tumorigenic effects without associated cardiotoxicity.Reynolds JG, Geretti E, Hendriks BS, Lee H, Leonard SC, Klinz SG, Noble CO, Lücker PB, Zandstra PW, Drummond DC, Olivier KJ Jr, Nielsen UB, Niyikiza C, Agresta SV, Wickham TJ.Toxicol Appl Pharmacol 201222676972
Derivation, expansion and differentiation of induced pluripotent stem cells in continuous suspension cultures.Fluri DA, Tonge PD, Song H, Baptista RP, Shakiba N, Shukla S, Clarke G, Nagy A, Zandstra PW.Nat Methods 201222447133
Tissue engineering 2.0: guiding self-organization during pluripotent stem cell differentiation.Woodford C, Zandstra PW.Curr Opin Biotechnol 201222444525
Predictive microfluidic control of regulatory ligand trajectories in individual pluripotent cells.Moledina F, Clarke G, Oskooei A, Onishi K, Günther A, Zandstra PW.Proc Natl Acad Sci U S A 201222334649
Rapid expansion of human hematopoietic stem cells by automated control of inhibitory feedback signaling.Csaszar E, Kirouac DC, Yu M, Wang W, Qiao W, Cooke MP, Boitano AE, Ito C, Zandstra PW.Cell Stem Cell 201222305571
Rational bioprocess design for human pluripotent stem cell expansion and endoderm differentiation based on cellular dynamics.Ungrin MD, Clarke G, Yin T, Niebrugge S, Nostro MC, Sarangi F, Wood G, Keller G, Zandstra PW.Biotechnol Bioeng 201222139975
A microfabricated platform to measure and manipulate the mechanics of engineered cardiac microtissues.Boudou T, Legant WR, Mu A, Borochin MA, Thavandiran N, Radisic M, Zandstra PW, Epstein JA, Margulies KB, Chen CS.Tissue Eng Part A 201222092279
Systematic engineering of 3D pluripotent stem cell niches to guide blood development.Purpura KA, Bratt-Leal AM, Hammersmith KA, McDevitt TC, Zandstra PW.Biomaterials 201222079776
Fiber alignment and coculture with fibroblasts improves the differentiated phenotype of murine embryonic stem cell-derived cardiomyocytes for cardiac tissue engineering.Parrag IC, Zandstra PW, Woodhouse KA.Biotechnol Bioeng 201222006660
An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming.Gabut M, Samavarchi-Tehrani P, Wang X, Slobodeniuc V, O'Hanlon D, Sung HK, Alvarez M, Talukder S, Pan Q, Mazzoni EO, Nedelec S, Wichterle H, Woltjen K, Hughes TR, Zandstra PW, Nagy A, Wrana JL, Blencowe BJ.Cell 201121924763
Creation of mouse embryonic stem cell-derived cardiac cell sheets.Matsuura K, Masuda S, Haraguchi Y, Yasuda N, Shimizu T, Hagiwara N, Zandstra PW, Okano T.Biomaterials 201121807408
High-throughput combinatorial cell co-culture using microfluidics.Tumarkin E, Tzadu L, Csaszar E, Seo M, Zhang H, Lee A, Peerani R, Purpura K, Zandstra PW, Kumacheva E.Integr Biol (Camb) 201121526262
Engineered heart tissue model of diabetic myocardium.Song H, Zandstra PW, Radisic M.Tissue Eng Part A 201121417718
Geometric control of cardiomyogenic induction in human pluripotent stem cells.Bauwens CL, Song H, Thavandiran N, Ungrin M, Massé S, Nanthakumar K, Seguin C, Zandstra PW.Tissue Eng Part A 201121417693
Engineered heart tissue enables study of residual undifferentiated embryonic stem cell activity in a cardiac environment.Dengler J, Song H, Thavandiran N, Massé S, Wood GA, Nanthakumar K, Zandstra PW, Radisic M.Biotechnol Bioeng 201121246514
High-throughput generation of hydrogel microbeads with varying elasticity for cell encapsulation.Kumachev A, Greener J, Tumarkin E, Eiser E, Zandstra PW, Kumacheva E.Biomaterials 201121095000
Incorporation of biomaterials in multicellular aggregates modulates pluripotent stem cell differentiation.Bratt-Leal AM, Carpenedo RL, Ungrin MD, Zandstra PW, McDevitt TC.Biomaterials 201120864164
Dynamic interaction networks in a hierarchically organized tissue.Kirouac DC, Ito C, Csaszar E, Roch A, Yu M, Sykes EA, Bader GD, Zandstra PW.Mol Syst Biol 201020924352
The use of vascular endothelial growth factor functionalized agarose to guide pluripotent stem cell aggregates toward blood progenitor cells.Rahman N, Purpura KA, Wylie RG, Zandstra PW, Shoichet MS.Biomaterials 201020684984
Synthetic peptide arrays for pathway-level protein monitoring by liquid chromatography-tandem mass spectrometry.Hewel JA, Liu J, Onishi K, Fong V, Chandran S, Olsen JB, Pogoutse O, Schutkowski M, Wenschuh H, Winkler DF, Eckler L, Zandstra PW, Emili A.Mol Cell Proteomics 201020467045
Enabling stem cell therapies through synthetic stem cell-niche engineering.Peerani R, Zandstra PW.J Clin Invest 201020051637
The AC133+CD38-, but not the rhodamine-low, phenotype tracks LTC-IC and SRC function in human cord blood ex vivo expansion cultures.Ito CY, Kirouac DC, Madlambayan GJ, Yu M, Rogers I, Zandstra PW.Blood 201019897585
Interrogating functional integration between injected pluripotent stem cell-derived cells and surrogate cardiac tissue.Song H, Yoon C, Kattman SJ, Dengler J, Massé S, Thavaratnam T, Gewarges M, Nanthakumar K, Rubart M, Keller GM, Radisic M, Zandstra PW.Proc Natl Acad Sci U S A 201019846783
Manipulation of signaling thresholds in "engineered stem cell niches" identifies design criteria for pluripotent stem cell screens.Peerani R, Onishi K, Mahdavi A, Kumacheva E, Zandstra PW.PLoS One 200919649273
Cell-cell interaction networks regulate blood stem and progenitor cell fate.Kirouac DC, Madlambayan GJ, Yu M, Sykes EA, Ito C, Zandstra PW.Mol Syst Biol 200919638974
Growth factors, matrices, and forces combine and control stem cells.Discher DE, Mooney DJ, Zandstra PW.Science 200919556500
An automated system for delivery of an unstable transcription factor to hematopoietic stem cell cultures.Csaszar E, Gavigan G, Ungrin M, Thérien C, Dubé P, Féthière J, Sauvageau G, Roy DC, Zandstra PW.Biotechnol Bioeng 200919266473
Alternative induced pluripotent stem cell characterization criteria for in vitro applications.Ellis J, Bruneau BG, Keller G, Lemischka IR, Nagy A, Rossant J, Srivastava D, Zandstra PW, Stanford WL.Cell Stem Cell 200919265656
Pairing cells to enhance fusion.Zandstra PW.Nat Methods 200919180092
Patterning mouse and human embryonic stem cells using micro-contact printing.Peerani R, Bauwens C, Kumacheva E, Zandstra PW.Methods Mol Biol 200919089347
Generation of human embryonic stem cell-derived mesoderm and cardiac cells using size-specified aggregates in an oxygen-controlled bioreactor.Niebruegge S, Bauwens CL, Peerani R, Thavandiran N, Masse S, Sevaptisidis E, Nanthakumar K, Woodhouse K, Husain M, Kumacheva E, Zandstra PW.Biotechnol Bioeng 200918767184
The systematic production of cells for cell therapies.Kirouac DC, Zandstra PW.Cell Stem Cell 200818940729
Soluble Flt-1 regulates Flk-1 activation to control hematopoietic and endothelial development in an oxygen-responsive manner.Purpura KA, George SH, Dang SM, Choi K, Nagy A, Zandstra PW.Stem Cells 200818772315
Don't look: growing clonal versus nonclonal neural stem cell colonies.Coles-Takabe BL, Brain I, Purpura KA, Karpowicz P, Zandstra PW, Morshead CM, van der Kooy D.Stem Cells 200818757294
Development of a gene-trap vector with a highly sensitive fluorescent protein reporter system for expression profiling.Tanaka TS, Davey RE, Lan Q, Zandstra PW, Stanford WL.Genesis 200818615730
Control of human embryonic stem cell colony and aggregate size heterogeneity influences differentiation trajectories.Bauwens CL, Peerani R, Niebruegge S, Woodhouse KA, Kumacheva E, Husain M, Zandstra PW.Stem Cells 200818583540
TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal.Varelas X, Sakuma R, Samavarchi-Tehrani P, Peerani R, Rao BM, Dembowy J, Yaffe MB, Zandstra PW, Wrana JL.Nat Cell Biol 200818568018
Functional immobilization of signaling proteins enables control of stem cell fate.Alberti K, Davey RE, Onishi K, George S, Salchert K, Seib FP, Bornhäuser M, Pompe T, Nagy A, Werner C, Zandstra PW.Nat Methods 200818552855
Analysis of the temporal and concentration-dependent effects of BMP-4, VEGF, and TPO on development of embryonic stem cell-derived mesoderm and blood progenitors in a defined, serum-free media.Purpura KA, Morin J, Zandstra PW.Exp Hematol 200818550259
Seeding bioreactor-produced embryonic stem cell-derived cardiomyocytes on different porous, degradable, polyurethane scaffolds reveals the effect of scaffold architecture on cell morphology.Fromstein JD, Zandstra PW, Alperin C, Rockwood D, Rabolt JF, Woodhouse KA.Tissue Eng Part A 200818333789
Reproducible, ultra high-throughput formation of multicellular organization from single cell suspension-derived human embryonic stem cell aggregates.Ungrin MD, Joshi C, Nica A, Bauwens C, Zandstra PW.PLoS One 200818270562
Synergy between erythropoietin and stem cell factor during erythropoiesis can be quantitatively described without co-signaling effects.Wang W, Horner DN, Chen WL, Zandstra PW, Audet J.Biotechnol Bioeng 200817969148
Phenotypic analysis of human embryonic stem cells.Ungrin M, O'Connor M, Eaves C, Zandstra PW.Curr Protoc Stem Cell Biol 200718785161
Prediction and testing of novel transcriptional networks regulating embryonic stem cell self-renewal and commitment.Walker E, Ohishi M, Davey RE, Zhang W, Cassar PA, Tanaka TS, Der SD, Morris Q, Hughes TR, Zandstra PW, Stanford WL.Cell Stem Cell 200718371337
Niche-mediated control of human embryonic stem cell self-renewal and differentiation.Peerani R, Rao BM, Bauwens C, Yin T, Wood GA, Nagy A, Kumacheva E, Zandstra PW.EMBO J 200717948051
Sensitivity analysis of intracellular signaling pathway kinetics predicts targets for stem cell fate control.Mahdavi A, Davey RE, Bhola P, Yin T, Zandstra PW.PLoS Comput Biol 200717616983
A non-contact suspension culture approach to the culture of osteogenic cells derived from a CD49elow subpopulation of human bone marrow-derived cells.Baksh D, Zandstra PW, Davies JE.Biotechnol Bioeng 200717614333
Engineering cardiac healing using embryonic stem cell-derived cardiac cell seeded constructs.Alperin C, Zandstra PW, Woodhouse KA.Front Biosci 200717485332
LIF-mediated control of embryonic stem cell self-renewal emerges due to an autoregulatory loop.Davey RE, Onishi K, Mahdavi A, Zandstra PW.FASEB J 200717356004
Clinically relevant expansion of hematopoietic stem cells with conserved function in a single-use, closed-system bioprocess.Madlambayan GJ, Rogers I, Purpura KA, Ito C, Yu M, Kirouac D, Casper RF, Zandstra PW.Biol Blood Marrow Transplant 200617084368
Understanding cellular networks to improve hematopoietic stem cell expansion cultures.Kirouac DC, Zandstra PW.Curr Opin Biotechnol 200616899360
Spatial organization of embryonic stem cell responsiveness to autocrine gp130 ligands reveals an autoregulatory stem cell niche.Davey RE, Zandstra PW.Stem Cells 200616825607
Dynamic changes in cellular and microenvironmental composition can be controlled to elicit in vitro human hematopoietic stem cell expansion.Madlambayan GJ, Rogers I, Kirouac DC, Yamanaka N, Mazurier F, Doedens M, Casper RF, Dick JE, Zandstra PW.Exp Hematol 200516219546
Culture development for human embryonic stem cell propagation: molecular aspects and challenges.Rao BM, Zandstra PW.Curr Opin Biotechnol 200516099157
Shear-controlled single-step mouse embryonic stem cell expansion and embryoid body-based differentiation.Fok EY, Zandstra PW.Stem Cells 200516081660
Soluble factor cross-talk between human bone marrow-derived hematopoietic and mesenchymal cells enhances in vitro CFU-F and CFU-O growth and reveals heterogeneity in the mesenchymal progenitor cell compartment.Baksh D, Davies JE, Zandstra PW.Blood 200516030193
Polyurethane films seeded with embryonic stem cell-derived cardiomyocytes for use in cardiac tissue engineering applications.Alperin C, Zandstra PW, Woodhouse KA.Biomaterials 200516023195
Clonal evolution of stem and differentiated cells can be predicted by integrating cell-intrinsic and -extrinsic parameters.Viswanathan S, Davey RE, Cheng D, Raghu RC, Lauffenburger DA, Zandstra PW.Biotechnol Appl Biochem 200515882145
Development of a perfusion fed bioreactor for embryonic stem cell-derived cardiomyocyte generation: oxygen-mediated enhancement of cardiomyocyte output.Bauwens C, Yin T, Dang S, Peerani R, Zandstra PW.Biotechnol Bioeng 200515778986
Scalable production of embryonic stem cell-derived cells.Dang SM, Zandstra PW.Methods Mol Biol 200515361674
Quantitative screening of embryonic stem cell differentiation: endoderm formation as a model.Chang KH, Zandstra PW.Biotechnol Bioeng 200415486933
The opportunity of stem cell bioengineering.Zandstra PW.Biotechnol Bioeng 200415486929
Signal processing underlying extrinsic control of stem cell fate.Davey RE, Zandstra PW.Curr Opin Hematol 200415257025
Controlled, scalable embryonic stem cell differentiation culture.Dang SM, Gerecht-Nir S, Chen J, Itskovitz-Eldor J, Zandstra PW.Stem Cells 200415153605
Sustained in vitro expansion of bone progenitors is cell density dependent.Purpura KA, Aubin JE, Zandstra PW.Stem Cells 200414688390
Towards predictive models of stem cell fate.Viswanathan S, Zandstra PW.Cytotechnology 200319002945
Supplementation-dependent differences in the rates of embryonic stem cell self-renewal, differentiation, and apoptosis.Viswanathan S, Benatar T, Mileikovsky M, Lauffenburger DA, Nagy A, Zandstra PW.Biotechnol Bioeng 200314574685
Scalable production of embryonic stem cell-derived cardiomyocytes.Zandstra PW, Bauwens C, Yin T, Liu Q, Schiller H, Zweigerdt R, Pasumarthi KB, Field LJ.Tissue Eng 200313678453
Fluorescence activated cell sorting reveals heterogeneous and cell non-autonomous osteoprogenitor differentiation in fetal rat calvaria cell populations.Purpura KA, Zandstra PW, Aubin JE.J Cell Biochem 200312938161
Adult human bone marrow-derived mesenchymal progenitor cells are capable of adhesion-independent survival and expansion.Baksh D, Davies JE, Zandstra PW.Exp Hematol 200312901978
Two-color image analysis discriminates between mineralized and unmineralized bone nodules in vitro.Purpura KA, Aubin JE, Zandstra PW.Biotechniques 200312813887
Modeling stem cell development by retrospective analysis of gene expression profiles in single progenitor-derived colonies.Madras N, Gibbs AL, Zhou Y, Zandstra PW, Aubin JE.Stem Cells 200212004081
Efficiency of embryoid body formation and hematopoietic development from embryonic stem cells in different culture systems.Dang SM, Kyba M, Perlingeiro R, Daley GQ, Zandstra PW.Biotechnol Bioeng 200211948451
Ligand/receptor signaling threshold (LIST) model accounts for gp130-mediated embryonic stem cell self-renewal responses to LIF and HIL-6.Viswanathan S, Benatar T, Rose-John S, Lauffenburger DA, Zandstra PW.Stem Cells 200211897869
Controlling culture dynamics for the expansion of hematopoietic stem cells.Madlambayan GJ, Rogers I, Casper RF, Zandstra PW.J Hematother Stem Cell Res 200111522231
Stem cell bioengineering.Zandstra PW, Nagy A.Annu Rev Biomed Eng 200111447065
A ligand-receptor signaling threshold model of stem cell differentiation control: a biologically conserved mechanism applicable to hematopoiesis.Zandstra PW, Lauffenburger DA, Eaves CJ.Blood 200010942360
Leukemia inhibitory factor (LIF) concentration modulates embryonic stem cell self-renewal and differentiation independently of proliferation.Zandstra PW, Le HV, Daley GQ, Griffith LG, Lauffenburger DA.Biotechnol Bioeng 200010918135
Concentration-dependent internalization of a cytokine/cytokine receptor complex in human hematopoietic cells.Zandstra PW, Jervis E, Haynes CA, Kilburn DG, Eaves CJ, Piret JM.Biotechnol Bioeng 199910099630
Ontogeny-associated changes in the cytokine responses of primitive human haemopoietic cells.Zandstra PW, Conneally E, Piret JM, Eaves CJ.Br J Haematol 19989674754
Advances in hematopoietic stem cell culture.Audet J, Zandstra PW, Eaves CJ, Piret JM.Curr Opin Biotechnol 19989588003
Cytokine manipulation of primitive human hematopoietic cell self-renewal.Zandstra PW, Conneally E, Petzer AL, Piret JM, Eaves CJ.Proc Natl Acad Sci U S A 19979114054
Cellular determinants affecting the rate of cytokine in cultures of human hematopoietic cells.Zandstra PW, Petzer AL, Eaves CJ, Piret JM.Biotechnol Bioeng 199718634073
Differential cytokine effects on primitive (CD34+CD38-) human hematopoietic cells: novel responses to Flt3-ligand and thrombopoietin.Petzer AL, Zandstra PW, Piret JM, Eaves CJ.J Exp Med 19968676076
Expansion of hematopoietic progenitor cell populations in stirred suspension bioreactors of normal human bone marrow cells.Zandstra PW, Eaves CJ, Piret JM.Biotechnology (N Y) 19947521647