Projects

Research at the forefront of regenerative medicine.

Multi-scale simulation of human tissue- and organo-genesis

Analysis of Spatially Organized Protein Expression in High-Throughput Screens
Project 2

Analysis of Spatially Organized Protein Expression in High-Throughput Screens

Chronic diseases are a great source of ﬁscal and emotional burden to society. To treat cancers and other hematologic indications, we need clinical scale bio-banks of blood progenitor cells that can be subsequently diﬀerentiated to desired mature blood phenotypes. Himanshu is conducting experiments with human embryonic organoids, or gastruloids, and using mathematical modelling to understand how biological events (such as signalling, cell activity, biochemical gradients) integrate across multiple spatiotemporal scales to yield the germ-layer cells (ectoderm, mesoderm, endoderm). He is using computational models to quantify the parameters that direct pluripotent stem cells to the mesodermal fate, use the model to identify trajectories to diﬀerentiate mesodermal cells to the blood-progenitor phenotype, and conﬁrm them in vitro. He will employ automated dynamic feedback bioreactors to upscale the production of these progenitor cells for clinical use. Eventually, he is interested in understanding how pathology emerges out of normal biology via an integrative approach encompassing multiscale computational models and multi-modular organoids.

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Project #2

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01. Project Title #1

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02. Project Title #2

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03. Project Title #3

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